Mustard's Introduction to Public Health

changing metabolic roles of the individual tissues. Most of this chapter is directed towards the enzyme lactate dehydrogenase since this has been the most widely studied and much is known about its development and evolution. Chapter 8 discusses isozymes occurring in insects, plants and lower organisms and is mainly concerned with genetic variations of a variety of enzymes. Chapter 9 is an excellent coverage of the role of isozymes in clinical biochemistry. The authors are specialists in this field and speak with authority on the subject. The last chapter lists technical methods utilized in demonstrating enzyme multiple forms and should provide newcomers to the field ample information and references. My overall impression of the book: very interesting and informative reading to newcomers to the field and to clinicians, but hardly an authoritative up-to-date account of the role of isozymes in biology and medicine. I would recommend to readers of this book that it be supplemented with more recent reviews on isozymes, namely: "Multiple Molecular Forms of Enzymes," Ann. N. Y. Acad. Sci., 151 (1968) Art. 1 and "Molecular Varieties of Isozymes" by C. L. Markert and G. S. Whitt, Experentia, 24 (1968), 977.