Diazepam and meperidine on arterial blood gases in healthy volunteers.

نویسندگان

  • E K Zsigmond
  • K Flynn
  • O A Martinez
چکیده

July, 1974 377 TERIAL blood gases and p11 may reflect the respiratory depression produced by tranquilizing and narcoticanalgesic agents used in premedication before surgical anesthesia. The absence of respiratory depression is one of the desirable qualities of an ideal premedicant or sedative drug. Therefore, it is essential to know if, and to what extent, a particular drug depresses respiration. The respiratory depressant effect of drugs is especially important in patients with pulmonary disease, in whom care must be exercised in selecting an agent that will not be detrimental to ventilation. Respiratory depression has been reported to occur following the use of phenothiazine tranquilizers and barhiturates.1’ Therefore, we wanted to verify the claim3’4 that diazepam does not induce significant respiratory depression or potentiate the depression caused by meperidine in healthy volunteers.

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عنوان ژورنال:
  • Journal of clinical pharmacology

دوره 14 7  شماره 

صفحات  -

تاریخ انتشار 1974