An unusual presentation of eruptive xanthoma
نویسندگان
چکیده
BACKGROUND Eruptive xanthomas are benign skin lesions caused by localized deposition of lipids in the dermis. The lesions are generally caused by elevated levels of serum triglycerides that leak through the capillaries and are phagocytosed by macrophages in the dermis. Clinical manifestation varies from asymptomatic skin lesions to intense pruritus and tenderness. METHODS We present a case of a middle-aged man admitted with diabetic ketoacidosis secondary to noncompliance with insulin. He was found to have skin lesions as multiple crusted papules on the extremities. Further evaluation revealed elevated serum triglycerides. A diagnosis of eruptive xanthomas was made on skin biopsy, and after starting treatment with lipid lowering agents his cutaneous lesions gradually subsided. CONCLUSION Appearance of eruptive xanthomas can signify the onset of serious complications. Prompt recognition of such skin manifestations is warranted to prevent development of fatal medical condition like coronary artery disease and pancreatitis.
منابع مشابه
Eruptive xanthomas presenting in tattoos.
©2015 8872147 Canada Inc. or its licensors CMAJ 1 A 26-year-old man with a history of uncontrolled hyperlipidemia presented with a six-month history of painful, multiple papules on his chest, back and limbs. The two-year-old tattoos on his right leg were covered by a linear arrangement of papules, suggesting a Koebner phenomenon (Figure 1A). A biopsy from the lesions on the tattoos showed infil...
متن کاملApoE enhances lipid uptake by macrophages in lipoprotein lipase deficiency during pregnancy.
A woman with primary lipoprotein lipase (LPL) deficiency developed marked hypertriglyceridemia, pancreatitis, eruptive xanthomas, and unusual palmar xanthomas during pregnancy. Hypotheses to account for the palmar xanthomas were that oxidative modification of triglyceride (TG)-rich lipoproteins occurred due to increased plasma residence time, or that their apolipoprotein E (apoE) content was ab...
متن کاملUnmasking of severe hypertriglyceridaemia associated with antipsychotic therapy by atypical eruptive xanthomas
متن کامل
Eruptive xanthomas as a cutaneous manifestation of hypertriglyceridemia: a case report.
A 28-year-old veteran presented to the Wilford Hall dermatology clinic in San Antonio, Texas, with a six-month history of a rash that his primary care physician diagnosed as molluscum contagiosum. The rash consisted of clusters of 3 to 6mm yellowish papules with erythematous borders that concentrated on the extensor surfaces of his extremities, lower back, and buttocks. A biopsy determined that...
متن کاملEruptive xanthoma.
History A two-month-old girl with unremarkable birth history presented with sudden onset of erythematous papules on the limbs and face for one week. There was no systemic upset, and she remained asymptomatic. Her sister had a history of hypertriglyceridaemia under treatment. The patient's other family members enjoyed good physical health and there was no family history of premature coronary hea...
متن کامل