Design and Evaluation of Mucoadhesive Buccal Drug Delivery Systems Containing Metoprolol Tartrate
نویسندگان
چکیده
In recent years, signiÞ cant interest has been shown in the development of novel bioadhesive dosage forms for mucosal delivery of drugs that attempt to overcome these limitations1. A bioadhesive dosage form necessitates the use of mucoadhesive polymers to adhere to mucosa and withstand salivation, tongue movement and swallowing for signiÞ cant period of time2. High molecular weight polymers are generally used for bioadhesion. Hydrogen bonding due to hydrophilic groups such as -COOH or -OH plays an important role in bioadhesion3.
منابع مشابه
Pharma Science Monitor an International Journal of Pharmaceutical Sciences a Review on Mucoadhesive Buccal Patch as a Novel Drug Delivery System
Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, NH-58, Baghpat Road-Bypass Crossing, Meerut-250005 (U.P), India ABSTRACT Drug release from mucoadhesive patches at predetermined rate in oral cavity having distinct advantages over traditional dosage forms as tablets, gels and solutions. This review provides brief information about method of preparation and e...
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significant effect on bioadhesive strength and in vitro drug release. It was found that carbopol gives higher bioadhesive strength than HPC. Comparatively HPC controls the drug release greater than carbopol. The optimized formulation follows non-Fickian release mechanism. The FT-IR and DTA studies indicate no physico-chemical interaction. Stability studies revealed that optimized formulation wa...
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