Prednisolone phosphate penetration into and through the cornea.
نویسندگان
چکیده
1. Waltman, S. R., and Kaufman, H. E.: Use of hydrophilic contact lenses to increase ocular penetration of topical drugs, INVEST. OPHTHALMOL. 9: 250, 1970. 2. Kaufman, H. E., Uotila, M. H., Gasset, A. R., et al.: The medical uses of soft contact lenses, Tr. Am. Acad. Ophthalmol. Otolaryngol. 75: 361, 1971. 3. Podos, S. M., Becker, B., Asseff, C , et al.: Pilocarpine therapy with soft contact lenses. Am. J. Ophthalmol. 73: 336, 1972. 4. Lerman, S., and Reininger, B.: Simulated sustained-release pilocarpine therapy and aqueous humor dynamics, Canad. J. Ophthalmol. 6: 14, 1971. 5. Tornqvist, G.: Comparative studies of the effect of pilocarpine on the pupil and on the refraction in two species of monkey (Cercopithecus ethiops and Macaca irus), INVEST. OPHTHALMOL. 3: 388, 1964. 6. Lyons, J. S., and Krohn, D. L.: Pilocarpine uptake by pigmented uveal tissue, Am. J. Ophthalmol. 75: 885, 1973. 7. Muller, H. K., Hockwin, O., and Kleifeld, O.: Die Bestimmung von Pilocarpin in menschlichen Kammerwasser mit Hilfe der Polarographie, Graefe's Arch. Ophthalmol. 162: 107, 1960. 8. Hockwin, O., Muller, H. K., and Blaser, U.: Nachweis von Pilocarpin im Kammerwasser von Kaninchenaugen mit Hilfe der Polarographie, Graefe's Arch. Ophthalmol. 167: 459, 1964. 9. Asseff, C. F., Weisman, R. L., Podos, S. M., et al.: Ocular penetration of pilocarpine, Am. J. Ophthalmol. 75: 212, 1973. 10. Harris, J. E.: In: Symposium on Ocular Therapy, Leopold, I., editor. St. Louis, 1968, The C. V. Mosby Company, vol. Ill, p. 99. 11. Anderson, R. A., and Cowle, J. B.: Influence of pH on the effect of pilocarpine on aqueous dynamics, Br. J. Ophthalmol. 52: 607, 1968. 12. Havener, W. H.: Ocular Pharmacology, ed. 2. St. Louis, 1970, The C. V. Mosby Company. 13. Chung, P. H., Chin, T. F., and Lach, J. L.: Kinetics of the hydrolysis of pilocarpine in aqueous solution, J. Pharmacol. Sci. 59: 1300, 1970.
منابع مشابه
Anti-inflammatory effectiveness of topically administered corticosteroids in the cornea without epithelium.
The present studies demonstrate that modification of the derivative of a given steriod base alters its anti-inflammatory potential as measured by suppression of leukocyte invasion of the cornea. A comparison of each drug's corneal bioavailability with its anti-inflammatory effectiveness shows the acetate derivative of prednisolone to be a more potent anti-inflammatory agent than the phosphate d...
متن کاملThe corneal penetration of trifluorothymidine, adenine arabinoside, and idoxuridine: a comparative study.
Trifluorothymidine (F3TdR) and idoxuridine (IDU) were observed to penetrate through the cornea from the epithelial side at a greater rate than adenine arabinoside (ARA-A) during in vitro corneal perfusions. Removal of the epithelium increased the rate of penetration of F3TdR and IDU by about twofold and the rate of ARA-A penetration by fivefold. The kinetics of antiviral penetration did not dis...
متن کاملOxygen consumption in the developing chick cornea
tides are seen in the in vivo experiment than in the in vitro one suggests that synthesis of polyglucose is regulated in the cell even under in vivo histochemical conditions. Another use of the enzyme-synthetic approach in the in vivo cornea has been shown in the present study. The number of synthesized polyglucose particles in the corneal epithelium indicates the amount of glucose-1-phosphate ...
متن کاملA MODIFICATION AND EXTENSION OF THE McREYNOLDS' OPERATION FOR PTERYGIUM*.
1. The penetration of sodium sulphacetaamide into the ocular tissues has been studied, both in living'rabbits and in isolated ocular tissues. 2. Application of the drug with a wetting agent, Duponal ME dry, increases the penetration of sodium sulphacetamide into and through the cornea. 3., Removal of the corneal epithelium causes a great increase in the penetration of the sulphonamide into antd...
متن کاملOn the barrier properties of the cornea: a microscopy study of the penetration of fluorescently labeled nanoparticles, polymers, and sodium fluorescein.
Overcoming the natural defensive barrier functions of the eye remains one of the greatest challenges of ocular drug delivery. Cornea is a chemical and mechanical barrier preventing the passage of any foreign bodies including drugs into the eye, but the factors limiting penetration of permeants and nanoparticulate drug delivery systems through the cornea are still not fully understood. In this s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Investigative ophthalmology
دوره 13 4 شماره
صفحات -
تاریخ انتشار 1974