814A Prospective Analysis of the Clinical Spectrum of Different Subtypes Human Enterovirus and Human Parechovirus
نویسندگان
چکیده
Human Enterovirus and Human Parechovirus Charles Obihara, MD, PhD; Stephanie De Crom, MD; Marceline Van Furth, MD, PhD; Ronald De Moor, MD; John Rossen, PhD; Esther Veldkamp, MD; Pediatrics, St. Elisabeth Hospital Tilburg, Tilburg, Netherlands; Maastricht University Medical Center, Maastricht, Netherlands; Free Univercity Medical Center, Amsterdam, Netherlands; Virology, University Medical Center Groningen, Griningen, Netherlands; Pediatrics, Amphia Hospital, Breda, Netherlands
منابع مشابه
Molecular detection of proteolytic activity of human parechovirus 2A protein by gene expression
Parechoviruses form one of the nine genera in the picornaviridae family, and include two human pathogens: Human parechovirus type1 and 2 (Hpev1 and Hpev2). The genome of picornaviruses encodes a single polyprotein, which undergoes a cleavage cascade performed by virus encoded proteases to give the final virus proteins. The primary cleavage occurs by 2A protein and this step is critical for vi...
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BACKGROUND Human non-polio enterovirus (EV) and human parechovirus (HPeV) are important pathogens of viral infection and aseptic meningitis in children. The aim of this study is to prospectively compare the incidence, clinical signs, blood and cerebrospinal fluid in EV and HPeV infected children. OBJECTIVES To compare the clinical symptoms and laboratory data of children with different EV and...
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The Parechovirus genus of the Picornaviridae family contains two species, Human parechovirus (HPeV) and Ljungan virus (LV). The HPeVs (including the former echoviruses 22 and 23, now HPeV type 1 (HPeV1) and HPeV2, respectively) cause a wide spectrum of disease, including aseptic meningitis, gastroenteritis, encephalitis, acute respiratory illness, and neonatal sepsis-like disease. The LVs were ...
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Introduction : Viral meningitis is an inflammation of the leptomeninges as a manifestation of central nervous system (CNS) infection, and more than 85% of viral meningitis cases are caused by non-polio enteroviruses. Molecular methods such as polymerase chain reaction (PCR) are increasingly used to detect and type non-polio enteroviruses. Here, we describe the impact of these viruses on asept...
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Background & Aim: Human parechovirus is a genus of picornaviruses which includes a number of important viruses of clinical significance. Recent sequence analysis suggests that human parechovirus type 1(HPEV-1) is distinct from other picornaviruses and lacks the motives believed to be involved in the protease function of 2A. The aim of this study was to analyse proteolytic activity of 3C pro...
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