Inhibition of Serotonin 5-ht2c Receptor Function through Heterodimerization: Receptor Dimers Bind Two Molecules of Ligand and One G-protein
نویسندگان
چکیده
Katharine Herrick-Davis, Ellinor Grinde, Timothy J. Harrigan, Joseph E. Mazurkiewicz Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208 Running title: ligand:dimer:G-protein stoichiometry Address Correspondence to: Katharine Herrick-Davis, Center for Neuropharmacology and Neuroscience, MC-136, Albany Medical College, 47 NewScotland Ave. Albany, NY 12208 tel: 518-262-6357; fax: 518-262-5799; E-Mail: [email protected]
منابع مشابه
G-protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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