Aminoglycoside antibiotics inhibit protein biosynthesis
نویسندگان
چکیده
RNA molecules have key roles in many essential biological processes, including protein synthesis, transcriptional regulation, mRNA splicing and retroviral replication. The structural diversity of RNA, together with the lack of known RNA repair mechanisms, make RNA a challenging and important target for therapeutic intervention [1]. Our understanding of the modes by which RNA is recognized by ligands is far from being comprehensive, although significant advances have been made [2]. In order to target pivotal bacterial or viral RNA sites, one would like to be able to identify well-defined binding motifs that will facilitate the design and synthesis of new binders [3].
منابع مشابه
Saccharide-RNA recognition.
Among saccharides, the antibiotics of the aminoglycoside family are the best-studied class of molecules interacting with RNA. By binding to RNA targets, aminoglycosides act as inhibitors of protein biosynthesis, they interfere with protein-RNA interaction of retroviral regulatory elements, and they inhibit the catalytic action of ribozymes. Here, we survey the available data on molecular struct...
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