The First Total Synthesis of Racemic Hydroxymoloka’iamine
نویسنده
چکیده
The enormous promise that the sea holds to provide potential lead pharmaceuticals has attracted great interest from the scientific community in the recent years. In an effort to isolate bio-active ingredients from marine sources, investigation of the Red Sea sponge Pseudoceratna arabica has led to the isolation and structure elucidation of the new brominated metabolite hydroxymoloka’iamine (1) [1]. This compound features a bromotyramine skeleton and has structural resemblance with the known metabolite moloka’iamine [2]. The evaluation of the cytotoxic activity against human colon tumor cells (HCT-116) of 1 has demonstrated that it was not toxic at a test dose of 10 μg mL−1, and such discoveries have important implications for further biological investigations of this class of compounds [1]. As a part of our ongoing research in the total synthesis of bio-active natural products [3, 4], we now wish to report a facile synthesis of racemic hydroxymoloka’iamine (1).
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