, Klaus Friedrich , Sergio Fazio , Giuseppe
نویسندگان
چکیده
Williams, William S. Bush, Alessandra Tacconelli, Klaus Friedrich, Sergio Fazio, Giuseppe Irene M. Predazzi, Antonis Rokas, Amos Deinard, Nathalie Schnetz-Boutaud, Nicholas D. Genetic Data Putting Pleiotropy and Selection Into Context Defines a New Paradigm for Interpreting Print ISSN: 1942-325X. Online ISSN: 1942-3268 Copyright © 2013 American Heart Association, Inc. All rights reserved. Dallas, TX 75231 is published by the American Heart Association, 7272 Greenville Avenue, Circulation: Cardiovascular Genetics doi: 10.1161/CIRCGENETICS.113.000126 2013;6:299-307; originally published online April 24, 2013; Circ Cardiovasc Genet. http://circgenetics.ahajournals.org/content/6/3/299 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://circgenetics.ahajournals.org/content/suppl/2013/04/24/CIRCGENETICS.113.000126.DC1.html Data Supplement (unedited) at:
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Putting pleiotropy and selection into context defines a new paradigm for interpreting genetic data.
BACKGROUND Natural selection shapes many human genes, including some related to complex diseases. Understanding how selection affects genes, especially pleiotropic ones, may be important in evaluating disease associations and the role played by environmental variation. This may be of particular interest for genes with antagonistic roles that cause divergent patterns of selection. The lectin-lik...
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