Effective Treatment of Transmissible Venereal Tumors in Dogs with Vincristine and IL2.
نویسندگان
چکیده
AIM To improve treatment of inoperable transmissible venereal tumors (TVTs) in dogs. Recently, we showed that TVT is sensitive to intratumoral treatment with interleukin-2 (IL2). In addition it is known that TVT is sensitive to intravenous treatment with vincristine. In the present study we tried to establish the therapeutic effect of intratumoral treatment with vincristine and IL2. PATIENTS AND METHODS We treated 12 dogs with TVT with 1-4 intratumoral treatments with vincristine and IL-2. Per treatment we used vincristine (0.5-0.7 mg/m(2)) and IL2 (2×10(6) units). The injections were given at weekly intervals. RESULTS Early therapeutic effects were: three complete regressions, four partial regressions, three stable disease, and two progressive disease. Late therapeutic effects were established 45-60 months after the first presentation; there were five complete regressions, no partial regressions, nor stable or progressive diseases. Interestingly, all five dogs with late therapeutic effects were in good health. No tumor recurrence was noted. CONCLUSION Intratumoral treatment of TVT with vincristine and IL2 appears to have impressive therapeutic effects.
منابع مشابه
Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy
The clinical utility of a life quality score during vincristine chemotherapy of dogs with canine transmissible venereal tumor (CTVT) was investigated using 93 tumor-bearing dogs in this prospective study. At diagnosis, clinical data and the performance status were evaluated according to a modified Karnofsky score (CKS) adapted for dogs. The animals were treated with vincristine sulphate (0.025m...
متن کاملTreatment of transmissible venereal tumors in dogs with intratumoral interleukin-2 (IL-2). A pilot study.
AIM To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2). PATIENTS AND METHODS We treated 13 dogs with 18 natural TVTs with IL-2. The tumors were treated with intratumoral application of 2×10(6) units IL-2. RESULTS Three months after injection of IL-2, the tumors in 2/13 dogs had regressed completely, those in 1/13 had...
متن کاملTransmissible Venereal Tumor: A Review (Transmisibil Venereal Tümör: Derleme)
Transmissible venereal tumor (TVT) is a neoplasm that can be transmitted between female and male dogs via mating by the physical transfer of viable tumor cells. The tumor may spread to different parts of the body through sniffing, licking, scratching or biting affected lesions. It can be also observed in wild carnivores. TVT is mostly located in the posterior wall of the vagina, in the joint of...
متن کاملClinical Pharmacokinetics and Effects of Vincristine Sulfate in Dogs with Transmissible Venereal Tumor (TVT)
This study was conducted to evaluate the pharmacokinetic characteristics of vincristine and their correlation with its clinical effects in dogs with transmissible venereal tumor (TVT). Dogs with TVT were intravenously administered vincristine sulfate at a dose of 0.7 mg/m(2) of body surface area. Blood samples were collected starting from 5 min to 48 hr after drug administration. The plasma con...
متن کاملRare Cases of Primary Canine Extragenital Transmissible Venereal Tumours
A 41⁄2 months old female Boxer pup, 6 years old Dachshund bitch and 10 years old Labrador dog were presented with extragenital transmissible venereal tumors. Based on the anamnesis, clinical symptoms and cytological examinations the cases were diagnosed as primary extragenital transmissible venereal tumors and histopathological examination of the specimens confirmed the diagnosis. The animals w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Anticancer research
دوره 35 6 شماره
صفحات -
تاریخ انتشار 2015