Regulation of Metabolic Processes in Mitochondria

genome. Experiments performed to determine relationships between these parameters in various nutrient media are described and interpreted. After discussing steady states, attention is focused upon the very interesting work on variation of synthesis rates when bacteria are transferred from a minimal to an enriched medium. Measurement of the rates for various classes of macromolecules reveals that RNA synthesis increases immediately upon shifting to an enriched medium, while there is a lag period in the increase of protein and DNA synthesis. The implications of this observation are discussed in detail and its ramifications are elucidated with reference to additional experiments which suggest mechanisms for the control of RNA and DNA synthesis. In the closing chapter, regulation of DNA synthesis and physicochemical properties of the bacterial nucleus bearing upon the problem of control are treated. The latter discussion is particularly relevant to the problem of relationships between in zvvo and in vitro experiments. Following an extensive list of references is an appendix consisting of reprints of four original papers. This monograph is recommended to one who would acquaint himself with the most recent work and thinking in the area. The only reservation held by this reviewer is in regard to the inclusion of a lengthy appendix of four reprints from journals available in any well-stocked library.