Modulatory Role of Phonophoresis Therapy in Erythrocyte Antioxidant Enzyme Activities on Freund’s Adjuvant Induced Arthritic Rats

The aim of the present study was to investigate the erythrocyte levels of lipid peroxidation (MDA), and antioxidant enzyme activities in Frund’s complete adjuvant (FCA) induced arthritis in rats. . Group I serves as normal. Group II to IV served as arthritis animals induced by FCA. Group III and IV treated with ultrasound and phonophoresis (Application of ultrasound along with Plumbago zeylanica root extract gel) respectively. Group II served as arthritic animals (Control). The phonphoresis has been conducted through Ultrasound device, one session per day for 3 weeks. Erythrocyte levels of malondialdehyde (MDA), the activities of antioxidant enzymes, as well erythrocyte sedimentation rates (ESR) were estimated in phonophoresis treated rats and Frund’s complete adjuvant (FCA) induced arthritis rats. Erythrocyte MDA concentrations were significantly higher in arthritis rats than those with phonophoresis treated and control rats. Erythrocyte SOD, GPx and CAT activities were found to be significantly lower in arthritis rats as compared with control rats. Ultrasound and phonophoresis (Application of ultrasound along with Plumbago zeylanica root extract gel) treated groups restored in the altered level of parameters were observed. Phonophoresis treated groups significantly restored the antioxidant activity as compared with ultrasound treated rats. These results indicate that application of phonophoresis to arthritic rats enhanced the antioxidant activity. © 2014 Universal Research Publications. All rights reserved