Clinical Implication of the Renin-angiotensin-aldosterone Blockers in Chronic Kidney Disease Undergoing Hemodialysis
نویسندگان
چکیده
The renin-angiotensin-aldosterone system (RAAS) blockers have been widely used in chronic kidney disease patients undergoing hemodialysis; however, whether RAAS blockers have beneficial effects for cardiovascular disease in those patients has not been fully defined. This review focuses on the effects of RAAS blockers in chronic kidney disease undergoing hemodialysis for cardiovascular disease.
منابع مشابه
Present and Future in the Treatment of Diabetic Kidney Disease
Diabetic kidney disease is the leading cause of end-stage renal disease. Albuminuria is recognized as the most important prognostic factor for chronic kidney disease progression. For this reason, blockade of renin-angiotensin system remains the main recommended strategy, with either angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. However, other antiproteinuric trea...
متن کاملAre renin-angiotensin-aldosterone system inhibitors lifesaving in chronic kidney disease?
Renin–angiotensin–aldosterone system (RAAS) inhibition has become the cornerstone of evidence-based therapies in cardiovascular disease, including patients with hypertension, high cardiovascular risk, left ventricular dysfunction after myocardial infarction, and heart failure with reduced ejection fraction (1–3). Both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor ...
متن کاملIn-Depth Review Potassium Homeostasis and Renin-Angiotensin-Aldosterone System Inhibitors
Inhibition of the renin-angiotensin-aldosterone system (RAAS) is a key strategy in treating hypertension and cardiovascular and renal diseases. However, RAAS inhibitors (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, aldosterone receptor antagonists, and direct renin inhibitors) increase the risk of hyperkalemia (serum potassium >5.5 mmol/L). This review evaluates the ...
متن کاملRole of the intrarenal renin-angiotensin-aldosterone system in chronic kidney disease.
The existence of local or tissue-based renin-angiotensin-aldosterone systems (RAAS) is well documented and has been implicated as a key player in the pathogenesis of cardiovascular and renal diseases. The kidney contains all elements of the RAAS, and intrarenal formation of angiotensin II not only controls glomerular hemodynamics and tubule sodium transport, but also activates a number of infla...
متن کاملDirect renin inhibition – a promising strategy for renal protection?
Activation of the renin-angiotensin-aldosterone system (RAAS) plays a key role in the progression of chronic kidney disease (CKD). RAAS inhibitors, such as angiotensin converting enzyme inhibitors (ACEis) and angiotensin II receptor blockers (ARBs), decrease the rate of progression of diabetic and non-diabetic nephropathies and are first-line therapies for CKD. Although these agents are highly ...
متن کامل