Critical analysis of treatment trials of rhesus macaques infected with Borrelia burgdorferi reveals important flaws in experimental design.

نویسندگان

  • Gary P Wormser
  • Phillip J Baker
  • Susan O'Connell
  • Andrew R Pachner
  • Ira Schwartz
  • Eugene D Shapiro
چکیده

A critical analysis of two treatment trials of Chinese rhesus macaques infected with Borrelia burgdorferi indicates that insufficient attention was placed on documenting the blood levels, pharmacokinetics, and pharmacodynamic parameters of the antibiotics used in this host. Consequently, it is impossible to conclude that the findings have validity in judging the efficacy of doxycycline or ceftriaxone for the treatment of Borrelia burgdorferi in this animal model.

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عنوان ژورنال:
  • Vector borne and zoonotic diseases

دوره 12 7  شماره 

صفحات  -

تاریخ انتشار 2012