Synthesis and biological evaluation of rigid polycyclic derivatives of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione.
نویسندگان
چکیده
Part of our research program concentrates on the discovery of new bioactive compounds prepared either by total synthesis or molecular transformation of compounds with bioactivity profiles. In this work we have focused our interest on chemical transformations of the Diels-Alder adduct tricyclo[6.2.1.0(2,7)]undeca-4,9-dien-3,6-dione in order to obtain cage-like compounds and derivatives, followed by an evaluation of their biological activity.
منابع مشابه
Biotransformation of a cage-like diels-alder adduct and derivatives by Mucor ramosissimus samutsevitsch
The present study aimed to evaluate the ability for biotransformation of the Diels-Alder adduct tricyclo[6.2.1.0(2,7)]undeca-4,9-dien-3,6-dione (1) and two synthetic derivatives by the saprobe fungus Mucor ramosissimus Samutsevitsch. Products from oxidation, isomerization and, regioselective and enantioselective reduction were achieved.
متن کاملDeposited in DRO : 08
The preparation of a number of alkyl and alkoxy derivatives of pentacyclo[5.4.0.0.0.0]undecane8,11-dione derivatives utilising a cheap, practical, low energy, “green”, single-pass continuous flow photochemical reactor is reported Their H and C NMR spectra are fully assigned, revealing some general characteristics not previously reported for this class of compound, which should aid the assignmen...
متن کاملTricyclo[6.2.1.02,7]undeca-4,9-diene-3,6-dione
The title compound, C(11)H(10)O(2), crystallizes with two independent mol-ecules in the asymmetric unit. In one mol-ecule, the dihedral angle between the mean planes of the C-C=C-C group of the diene unit and essentially planar cyclo-hexene ring is 51.07 (9)°, while in the other mol-ecule it is 54.49 (12)°. In the crystal structure, weak inter-molecular C-H⋯O inter-actions link the mol-ecules i...
متن کاملREACTION OF 4-METHYL- 1 2,4-TRIAZOLINE- 3,5-DIONE WITH DI AND TRI-SUBSTITUTED STYRENES S.E. Mallakpour* and G.B. Butler**
2,4,6-Triisopropylstryrene was synthesized in a single step via the Witting Reaction from the corresponding aldehyde. The reaction of three styrene's derivatives, 2,6-dimethylstyrene, 2,4,6-trimethylstyrene, and 2,4,6- triisopropylstyrene with 4-methyl-l,2,4-triazoline-3,5-dion(M eTD) was investigated. These reactions are instantaneous at room temperature and lead to the formation of 2: 1 ...
متن کامل5-Methyl-2,4-bis(methylsulfanyl)tricyclo[6.2.1.02,7]undeca-4,9-diene-3,6-dione1
The structure analysis of the title compound, C(14)H(16)O(2)S(2), shows the SMe and H atoms of the bond linking the six-membered rings to be syn and also to be syn to the bridgehead -CH(2)- group. Each of the five-membered rings adopts an envelope conformation at the bridgehead -CH(2)- group. The dione-substituted ring adopts a folded conformation about the 1,4-C⋯C vector, with the ketone group...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 12 2 شماره
صفحات -
تاریخ انتشار 2007