Contrast nephropathy: isosmolar and low-osmolar contrast media.

A meta-analysis of the renal safety of isosmolar iodixanol compared with low-osmolar contrast media.

OBJECTIVES We sought to compare the nephrotoxicity of isosmolar contrast medium (IOCM) iodixanol with low-osmolar contrast media (LOCM) and to identify predictors of contrast-induced nephropathy (CIN). BACKGROUND Contrast-induced nephropathy is a serious complication of diagnostic and interventional procedures. METHODS Pooled individual patient data (n = 2,727) from 16 double-blind, randomi...

Contrast media induced nephropathy: CONTRAST There is an ongoing controversy on the impact of iso- osmolar contrast agents on contrast media induced nephropathy (CIN). The COntrast Media and Neph- roToxicity Following Coronary Revascularization by AngioplaSTy

There is an ongoing controversy on the impact of isoosmolar contrast agents on contrast media induced nephropathy (CIN). The COntrast Media and NephroToxicity Following Coronary Revascularization by AngioplaSTy (CONTRAST) randomized 324 patients with impaired renal function undergoing PCI to receive either the iso-osmolar contrast medium iodixanol 320 (Visipaque ) or the low-osmolar contrast me...

Iso-Osmolar versus Low-Osmolar Contrast Media in Reducing Contrast Induced Nephropathy in Patient with Renal Impairment Undergoing Coronary Angiography

S-cystatin C formulae or combination of s-cystatin C and s-creatinine formulae do not improve prediction of GFR.

of the NEPHRIC trial (n = 129 patients), which shows a smaller incidence of contrast-induced nephropathy by using iso-osmolar contrast media [2]. However, we also have not changed our routine daily clinical approach in 2008 by using the low-osmolar contrast media, because the published results were conflicting in the last 2 years. In our paper, we emphasized these conflicting results concerning...

Contrast-induced nephropathy; A literature review.

CONTEXT Contrast-induced nephropathy (CIN) is a common cause of acute kidney dysfunction. EVIDENCE ACQUISITIONS Directory of Open Access Journals, Google Scholar, PubMed, EBSCO and Web of Science have been searched. RESULTS It is necessary to identify at risk patients at early stages to implement preventive strategies to decrease the incidence of this nephropathy. However, mechanisms of CIN...

Renal Safety of Iodinated Contrast Media Depending on Their Osmolarity – Current Outlooks

Iodinated contrast media (ICM) are commonly administered pharmaceutical agents. Most often they are used intravenously and intraarterially. Although iodinated contrast agents are relatively safe and widely used, adverse events occur and questions remain about their use, safety, and interactions. The most important adverse effects of contrast media include hypersensitivity reactions, thyroid dys...