A new bioactive norquinone-methide triterpene from Maytenus scutioides.

نویسندگان

  • A G González
  • N L Alvarenga
  • I L Bazzocchi
  • A G Ravelo
  • L Moujir
چکیده

By antimicrobial and cytotoxic-guided fractionation, a bioactive norquinone-methide triterpene, 15 alpha-hydroxypristimerin, was isolated from a South American medicinal plant, Maytenus scutioides. Its structure was determined on the basis of spectroscopic evidence. Successful chemical transformation of pristimerin to netzahualcoyene indicates that the 15-hydroxy compounds seems to be a possible percursor of 14(15)-ene-quinone-methide-triterpenoids in the biogenetic pathway.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Two cangorosin A type triterpene dimers from Maytenus chuchuhuasca.

Two new cangorosin A type triterpene dimers, which composed of two triterpene units jointed by two ether linkages between the A and B rings, were isolated from the Brazilian medicinal plant "xuxuá" (Maytenus chuchuhuasca). Structures of new isolates, xuxuasins A (1) and B (2), were established based on several spectroscopic evidences.

متن کامل

A comparative chemical study of Maytenus ilicifolia mart. reiss and Maytenus robusta reiss (Celastraceae).

This work describes a comparative qualitative and quantitative chemical analysis of Maytenus ilicifolia and Maytenus robusta (Celastraceae), extracts by high-resolution gas chromatography (HRGC), using external standards as the method of determination and thin layer chromatographic (TLC). The results show that both plants have a similar chromatographic profile. However, M. robusta exhibited abo...

متن کامل

Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms.

Triterpenes are interesting compounds because they play an important role in cell homeostasis and a wide variety exhibiting defense functions is produced by plant secondary metabolism. Those same plant secondary metabolites also exhibit biological properties with promising therapeutic potential as anti-inflammatory and antitumor agents. Friedelin is a triterpene ketone with anti-inflammatory an...

متن کامل

Celastrols as inducers of the heat shock response and cytoprotection.

Alterations in protein folding and the regulation of conformational states have become increasingly important to the functionality of key molecules in signaling, cell growth, and cell death. Molecular chaperones, because of their properties in protein quality control, afford conformational flexibility to proteins and serve to integrate stress-signaling events that influence aging and a range of...

متن کامل

Chem. Pharm. Bull. 52(6) 739—746 (2004)

compounds from South American medicinal plants, we became interested in medicinal plants belonging to the genus Maytenus (Celastraceae). The plants of this genus are widely used in folk medicine in South America and are rich sources of terpenoids including dihydro-b-agarofuran sesquiterpenes, highly oxidized friedelane triterpenes, and several types of triterpene dimers. Among these, triterpene...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Planta medica

دوره 64 8  شماره 

صفحات  -

تاریخ انتشار 1998