Probing command following in patients with disorders of consciousness using a brain-computer interface.

نویسندگان

  • Dorothée Lulé
  • Quentin Noirhomme
  • Sonja C Kleih
  • Camille Chatelle
  • Sebastian Halder
  • Athena Demertzi
  • Marie-Aurélie Bruno
  • Olivia Gosseries
  • Audrey Vanhaudenhuyse
  • Caroline Schnakers
  • Marie Thonnard
  • Andrea Soddu
  • Andrea Kübler
  • Steven Laureys
چکیده

OBJECTIVE To determine if brain-computer interfaces (BCIs) could serve as supportive tools for detecting consciousness in patients with disorders of consciousness by detecting response to command and communication. METHODS We tested a 4-choice auditory oddball EEG-BCI paradigm on 16 healthy subjects and 18 patients in a vegetative state/unresponsive wakefulness syndrome, in a minimally conscious state (MCS), and in locked-in syndrome (LIS). Subjects were exposed to 4 training trials and 10 -12 questions. RESULTS Thirteen healthy subjects and one LIS patient were able to communicate using the BCI. Four of those did not present with a P3. One MCS patient showed command following with the BCI while no behavioral response could be detected at bedside. All other patients did not show any response to command and could not communicate with the BCI. CONCLUSION The present study provides evidence that EEG based BCI can detect command following in patients with altered states of consciousness and functional communication in patients with locked-in syndrome. However, BCI approaches have to be simplified to increase sensitivity. SIGNIFICANCE For some patients without any clinical sign of consciousness, a BCI might bear the potential to employ a "yes-no" spelling device offering the hope of functional interactive communication.

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عنوان ژورنال:
  • Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

دوره 124 1  شماره 

صفحات  -

تاریخ انتشار 2013