Functional implications of the pulmonary microcirculation. An update.

Vulnerability of Prepubertal Mice Testis to Iron Induced Oxidative Dysfunctions In Vivo and Functional Implications

Background The present study describes the susceptibility of prepubertal testis of mice to prooxidant induced oxidative impairments both under in vitro and in vivo exposure conditions. MaterialsAndMethods Following in vitro exposure to iron (5,10 and 25 M), oxidative response measured in terms of lipid peroxidation and hydroperoxide levels in testis of pre pubertal mice (4 wk) was more robust c...

Fibrogenesis: Mechanisms, Dynamics and Clinical Implications

Fibrosis is the pathological condition resulting in the growth of excess fibrous connective tissue in an organ or body system as a reparative or reactive process. In the field of clinical pathology, clinicians and medical scientists are endeavoring to translate experimental knowledge into effective, innovative treatments for a range of fibrotic conditions. The amelioration of whole organ functi...

Berberine Ameliorates Renal Functional Disorders and Pulmonary Tissue Injury Following Renal Ischemia/Reperfusion in Rats

Introduction: This study investigated the effect of berberine on renal dysfunction and histological damages of the lung induced by renal ischemia/ reperfusion at an early stage. Methods: There were four experimental groups of adult male rats (n=7). Seven days before induction of ischemia, the Ber+I/R group received oral (by gavage) berberine (15 mg/kg/day) while the I/R group received distil...

Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging.

Modern functional brain mapping relies on interactions of neuronal electrical activity with the cortical microcirculation. The existence of a highly localized, stimulus-evoked initial deoxygenation has remained a controversy. Here, the activity-dependent oxygen tension changes in the microcirculation were measured directly, using oxygen-dependent phosphorescence quenching of an exogenous indica...

Ethical guidelines for publication in Clinical Hemorheology and Microcirculation: Update 2016.