Anti ulcer potential of ethanolic extract of Syzygiumalternifolium leaves on Albino rats

Background: The fruit juice of Syzygium alternifolium is used to cure stomach ache and ulcers, while fruit pulp and alcoholic extract of seeds posses anti-diabetic properties. The leaves of plants are claimed for anti-ulcer properties by folklore medicine. Objective: To investigate the antiulcer activity of Ethanolic extract of Syzygium alternifolium (EESA) leaves by Pylorus ligation (Shay rat model), stress ulcers by cold water immersion, Indomethacin induced ulcers, ethanol induced mucosal damage (cytoprotective activity) in albino rats. Materials and methods: The different concentrations of EESA 1gm/kg and 2gm/kg and Ranitidine as standard 150mg/kg and saline (control) were administered orally to albino rats (n=6 animals per group). The antiulcer effect was investigated by measuring ulcer index, determination of total acidity, acid volume and pH of gastric juice. Results: The EESA showed significant (p<0.001) reduction in the ulcer index, reduction in the volume of gastric contents. Total acidity and PH was increased as compared to control group in all the models. Conclusion: The results of the study reveal that the EESA has antiulcer activity which supports the claims in folklore medicine.