Optimization of electrode position and electric pulse amplitude in electrochemotherapy
نویسندگان
چکیده
Electrochemotherapy (ECT) is an effective local tumor therapy performed by the administration of chemotherapeutic drugs followed by the application of local high-voltage electric pulses.1, 2 The electric pulses cause transient structural changes (electroporation) of tumor cell membranes and thus increase the entrance of the chemotherapeutic drugs. This potentiates the chemotherapeutic effect and lowers the required drug dose.3 Numerous studies have demonstrated ECT to be a very efficient treatment in various tumor types; in recent years, it has become a treatment of choice for cutaneous and subcutaneous tumor nodules of different histologies.4-9 Two conditions have to be met for ECT to be efficient: 1) a sufficient amount of chemotherapeutic drug has to be present in the Radiol Oncol 2008; 42(2): 93-101. doi:10.2478/v10019-008-0005-5
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