Hemoglobin - Alpha Locus 1

Alpha-thalassemias are characterized by decreased hemoglobin alpha chain synthesis; alpha-zerothalassemia being the condition where no normal alpha globin is produced, and alpha-plus-thalassemia being the condition where there is reduced globin production. There are two alpha globin genes per haploid genome, and alpha thalassemia abnormalities can result from one to four gene deletions. A single alpha gene mutation leads to the silent carrier state (alpha-plus). The two gene mutation is a minor clinical condition, with mild hypochromic, microcytic anemia.