Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth.
نویسندگان
چکیده
A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.
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ورودعنوان ژورنال:
- Neuroscience letters
دوره 202 3 شماره
صفحات -
تاریخ انتشار 1996