Development of the neuromuscular system during asexual propagation in an invertebrate chordate.

Botryllus schlosseri, an emerging model for the study of aging, stem cells, and mechanisms of regeneration

The decline of tissue regenerative potential with the loss of stem cell function is a hallmark of mammalian aging. We study Botryllus schlosseri, a colonial chordate which exhibits robust stem cell-mediated regeneration capacities throughout life. Larvae, derived by sexual reproduction and chordate development, metamorphose to clonal founders that undergo weekly formation of new individuals by ...

The genome sequence of the colonial chordate, Botryllus schlosseri

Botryllus schlosseri is a colonial urochordate that follows the chordate plan of development following sexual reproduction, but invokes a stem cell-mediated budding program during subsequent rounds of asexual reproduction. As urochordates are considered to be the closest living invertebrate relatives of vertebrates, they are ideal subjects for whole genome sequence analyses. Using a novel metho...

Investigation on sexual and asexual propagation methods of damask rose (rosa damascena mill.)

Aging in the colonial chordate, Botryllus schlosseri

What mechanisms underlie aging? One theory, the wear-and-tear model, attributes aging to progressive deterioration in the molecular and cellular machinery which eventually lead to death through the disruption of physiological homeostasis. The second suggests that life span is genetically programmed, and aging may be derived from intrinsic processes which enforce a non-random, terminal time inte...

Functional analysis of Pitx during asexual regeneration in a basal chordate.

Embryogenesis in ascidians is the classic example of mosaic development, yet within this phyla a number of colonial species exist which as adults can reproduce entire bodies asexually. The colonial ascidian Botryllus schlosseri is an excellent model to study this process: on a weekly basis it regenerates all somatic and germline tissues, and while these processes have been characterized morphol...