A Broader View of Cancer Cytogenetics: From Nuclear Aberrations to Cytogenomic Abnormalities

A brief review on chemical agents involved in chromosomal aberrations in military wars

Chromosomal abnormalities are able to produce genetic instability, which is the main cause of many diseases. Cytogenetics is analysis of any kind of chromosomal abnormalities. Chromosomal alterations can be divided into structural and numerical abnormalities, both of which play a significant role in the development of many diseases, particularly cancer. Today, most cytogenetic analyzes are perf...

Cytoplasmic Her2/neu immunohistochemical staining in breast cancer; From a molecular point of view

Changes in and Efficacies of Indications for Invasive Prenatal Diagnosis of Cytogenomic Abnormalities: 13 Years of Experience in a Single Center

BACKGROUND Because the future application of cell-free fetal DNA screening is expected to dramatically improve the diagnostic yield and reduce unnecessary invasive procedures, it is time to summarize the indications of invasive prenatal diagnosis. This retrospective study was performed to evaluate the changes and efficacies of indications of invasive procedures for detecting cytogenomic abnorma...

Microarray-Based Cytogenetic Testing Illuminates Congenital Abnormalities, Cancer

Trilochan Sahoo, M.D. is an expert in the development, evaluation, and implementation of microarray-based cytogenomic technologies. A medical doctor by training, his interest in human genetics began early on in his career during his post-doctoral fellowship at Duke University. “My research was focused on identifying the cause of a group of Mendelian genetic disorders,” Dr. Sahoo said. “I moved ...

Human Cytogenetics: from Classical to Molecular Karyotyping

The establishment of human diploid chromosome number (Tjio and Levan, 1956), have led to the foundations of human cytogenetics. Since then, due to the rapid developments of new techniques for chromosome analysis, many other chromosome disorders were recognized. The introduction of banding techniques, yielding a highly reproducible banding pattern, allowed the reliable identification of every si...