Production and NK Cell Activation Interleukin-12 and Gamma Interferon Mice Is Associated with Differences in Expression between BALB/c and C57BL/6 Variation in Adenovirus Transgene
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Variation in adenovirus transgene expression between BALB/c and C57BL/6 mice is associated with differences in interleukin-12 and gamma interferon production and NK cell activation.
The innate immune response against replication-defective adenoviruses (Ad) is poorly defined. We and others have previously observed striking differences in the rate at which the Ad vector itself or the virus encoding a variety of transgenes is eliminated in different mouse strains. Here, we report that Ad infection of BALB/ mice is associated with sixfold-higher levels of serum alanine aminotr...
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