Organelle structure and biogenesis
نویسندگان
چکیده
What controls the dynamics of the transitional ER? Secretory proteins exit from the endoplasmic reticulum (ER) at specialized transitional ER (tER) sites. Benjamin Glick (University of Chicago) described the role of Sec16 in regulating tER organization in the yeast Pichia pastoris. Membrane-associated Sec16 seems to slow ER export. A mutation that redistributes Sec16 to the cytosol relieves this restraint, thereby accelerating both ER export and tER dynamics. Cells may regulate ER export by modulating the level of membrane-associated Sec16.
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