The Interaction between Epigenetics, Nutrition and the Development of Cancer
نویسندگان
چکیده
Unlike the genome, the epigenome can be modified and hence some epigenetic risk markers have the potential to be reversed. Such modifications take place by means of drugs, diet or environmental exposures. It is widely accepted that epigenetic modifications take place during early embryonic and primordial cell development, but it is also important that we gain an understanding of the potential for such changes later in life. These "later life" epigenetic modifications in response to dietary intervention are the focus of this paper. The epigenetic modifications investigated include DNA methylation, histone modifications and the influence of microRNAs. The epigenotype could be used not only to predict susceptibility to certain cancers but also to assess the effectiveness of dietary modifications to reduce such risk. The influence of diet or dietary components on epigenetic modifications and the impact on cancer initiation or progression has been assessed herein.
منابع مشابه
درمان سرطان بر پایه اپی ژنتیک
Introduction: Epigenetics involves the study of heritable changes in the regulation of gene activity and expression that are not dependent on gene sequence. Main mechanisms of epigenetic modifications are DNA methylation, Histone modification and Nucleosome positioning. Several studies have shown that these modifications are related to cancer initiation, progression or tumor metastasis. In cont...
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