Hemostatic- and fibrinolytic-affecting agents in experimental vascular sensitization.

THAT multiple alterations in hemostasis may occur during subacute hjpersensitivity reactions in the rabbit was suggested by demonstrations of physiological and histological changes during experimental procedures.^ An initial delay in blood coagulation was followed by the subsequent development of intralummal aggregates of formed elements of the blood and of thrombi in association with inflammatory involvement of vascular and perivaseular tissue. Since pathophysiological alterations in the histopathogenesis of cardiovascular-renal sensitization can only be partially explained by histamine and serotonin release, consideration was therefore given to possible participating roles for components of hemostatic and fibrinolytic systems. Evidence for their association with other hypersensitivity mechanisms has been offered and reviewed.