Hydrallazine-induced SLE-like syndrome presenting as a leg ulcer.

نویسندگان

  • M W Kissin
  • R C Williamson
چکیده

We believe that hypercalcaemia after tamoxifen may signify tumour response and be a reason for continuing with tamoxifen and treating the hypercalcaemia. This is supported by a report of tamoxifen "flare" in metastatic breast cancer and the observation that acute exacerbation of bone pain in patients with breast cancer after tamoxifen may be associated with tumour response.'5 The mechanism of tamoxifeninduced tumour response needs further investigation, since acute hypercalcaemia is not seen in patients responding to chemotherapy or oophorectomy.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Drug-induced nephrotic syndrome

Many drugs may produce a syndrome closely resembling spontaneous systemic lupus erythematosus (SLE). Those most commonly implicated are hydrallazine, isoniazid, and procainamide. Drugs less commonly implicated include the following. Antimicrobials-sulphonamides, penicillins, tetracycline, strepto-`mycin, and para-amino salicylic acid; Antithyroid drugs-methylthiouracil and propylthiouracil; Ant...

متن کامل

سندرم شبه اسکلرودرمی معرفی یک بیمار نادر (سندرم ورنر)

Scleroderma-like syndromes are a group of disorders that mimic systemic sclerosis. Werner’s syndrome is a genetically inherited syndrome that can be misdiagnosed as systemic scleroderomia. The syndrome is charachterized by sclerosis or stiffening of the skin, progeris, bilatera l juvenile cataract, endocrinopathies, premature coronary artery disease, alopecia, nail plate changes, hyperpigmentat...

متن کامل

مدل‌ها و روش‌های حیوانی ترمیم زخم: مقاله مروری

Wound healing and reduction of its recovery time is one of the most important issues in medicine. Wound is defined as disruption of anatomy and function of normal skin. This injury could be the result of physical elements such as  surgical incision, hit or pressure cut of the skin and gunshot wound. Chemical or caustic burn is another category of wound causes that can be induced by acid or base...

متن کامل

Circulating immune complexes appearing in Goodpasture's syndrome.

Recently Bartoli et all described a patient with acute hepatic necrosis that occurred two days after treatment with hydrallazine 50 mg daily. The diagnosis was supported by biopsy and rechallenge with the drug. The patient was definitely jaundiced and complained of right upperquadrant pain with nausea and vomiting. We think that our case is important because it provides corroborative evidence o...

متن کامل

ANA Negative Systemic Lupus Erythematosus Leading to CTEPH, TTP-Like Thrombocytopenia, and Skin Ulcers

SLE affects almost every organ system, with differing degrees of severity. During its clinical course periods of flares may alternate with periods of remission culminating in disease and therapy related damage. We describe a case of ANA negative SLE with severe thrombocytopenia, cutaneous vasculitis, antiphospholipid antibody syndrome, and pulmonary artery hypertension. As there is no definitiv...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • British medical journal

دوره 2 6201  شماره 

صفحات  -

تاریخ انتشار 1979