A novel antioxidant action of ethanolamine plasmalogens in lowering the oxidizability of membranes.
نویسندگان
چکیده
We have demonstrated a novel antioxidant action of ethanolamine plasmalogens both in protecting cholesterol from oxidation by free radicals and in lowering the oxidizability of membranes, along with the action of scavenging radicals, by the oxygen-uptake method using large unilamellar vesicles and the water-soluble azo-radical initiator, AAPH [2,2'-azobis-(2-amidino-propane) dihydrochloride].
منابع مشابه
Plasmalogen biosynthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membranes
Alkenyl ether phospholipids are a major sub-class of ethanolamine- and choline-phospholipids in which a long chain fatty alcohol is attached at the sn-1 position through a vinyl ether bond. Biosynthesis of ethanolamine-containing alkenyl ether phospholipids, plasmalogens, is regulated by modulating the stability of fatty acyl-CoA reductase 1 (Far1) in a manner dependent on the level of cellular...
متن کاملBiosynthesis of Plasmalogens in Brain 2.1 General Considerations and Distribution of Plasmalogens in Brain Plasmalogens account for the major portion of the ethanolamine glycerophospholipids
Plasmalogens account for the major portion of the ethanolamine glycerophospholipids in the adult human brain (50%), but the brain of newborn babies has low levels (7% of total phospholipids mass) (Horrocks and Sharma, 1982). Levels of ethanolamine plasmalogen (PlsEtn) increase rapidly during the intense period of myelination and ethanolamine glycerophospholipids of myelin sheath contain up to 7...
متن کاملBiosynthesis of Plasmalogens in Brain 2.1 General Considerations and Distribution of Plasmalogens in Brain
Plasmalogens account for the major portion of the ethanolamine glycerophospholipids in the adult human brain (50%), but the brain of newborn babies has low levels (7% of total phospholipids mass) (Horrocks and Sharma, 1982). Levels of ethanolamine plasmalogen (PlsEtn) increase rapidly during the intense period of myelination and ethanolamine glycerophospholipids of myelin sheath contain up to 7...
متن کاملBiosynthesis of Plasmalogens in Brain 2.1 General Considerations and Distribution of Plasmalogens in Brain
Plasmalogens account for the major portion of the ethanolamine glycerophospholipids in the adult human brain (50%), but the brain of newborn babies has low levels (7% of total phospholipids mass) (Horrocks and Sharma, 1982). Levels of ethanolamine plasmalogen (PlsEtn) increase rapidly during the intense period of myelination and ethanolamine glycerophospholipids of myelin sheath contain up to 7...
متن کاملPlasmalogens in human serum positively correlate with high- density lipoprotein and decrease with aging.
AIM The objective of the present study was to propose plasmalogens as a beneficial factor in human plasma by showing a highly positive correlation with high-density lipoprotein (HDL) and a significant reduction with aging. METHODS For 148 elderly subjects suspected of coronary artery disease (CAD), clinical characteristics such as coronary stenosis, hyperlipidemia, abnormal glucose tolerance,...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 32 Pt 1 شماره
صفحات -
تاریخ انتشار 2004