The Effect of 17β-estradiol on Astrocyte Density in Hippocampal Ca1 Region during the Aging Process
نویسندگان
چکیده
The aging process affects all body tissues including the brain and different hormones are reduced with aging in mammals. This research was performed to study the effects of 17β-estradiol on astrocyte density in CA1 region of hippocampus during the aging process. Female Wistar rats were divided into the following five groups: immature rats, mature rats in metestrus phase, mature rats treated with 17βestradiol, old rats in metestrus phase and old rats treated with 17β-estradiol. The groups received 50 μg/kg 17β-estradiol subcutaneously daily injections for a period of 7 days. The groups in metestrus phase were detected on the basis of observed cells in the vaginal smear. The results revealed increased astrocyte density in groups possessing a better condition in estradiol hormone.
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