Carnitine Palmitoyltransferase-1b (CPT1b) Deficiency Aggravates Pressure- Overload-Induced Cardiac Hypertrophy due to Lipotoxicity
نویسندگان
چکیده
Running title: He et al.; CPT1b deficiency aggravates pressure-overload-induced cardiac hypertrophy Abstract: Background-Carnitine palmitoyltransferase 1(CPT1) is a rate-limiting step of mitochondrial E
منابع مشابه
Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity.
BACKGROUND Carnitine palmitoyltransferase-1 (CPT1) is a rate-limiting step of mitochondrial β-oxidation by controlling the mitochondrial uptake of long-chain acyl-CoAs. The muscle isoform, CPT1b, is the predominant isoform expressed in the heart. It has been suggested that inhibiting CPT1 activity by specific CPT1 inhibitors exerts protective effects against cardiac hypertrophy and heart failur...
متن کاملHeart Failure Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity
Received November 9, 2011; accepted August 17, 2012. From the Departments of Nutrition Sciences (L.H., T.K., Q.L., J.L., P.W., Y.Z., Q.Y., Y.D.) and Pharmacology (J.P.), University of Alabama at Birmingham, and Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL (P.A.W.). The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/...
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