Clinical trials of pharmacological therapies in acute heart failure syndromes: lessons learned and directions forward.

نویسندگان

  • G Michael Felker
  • Peter S Pang
  • Kirkwood F Adams
  • John G F Cleland
  • Gad Cotter
  • Kenneth Dickstein
  • Gerasimos S Filippatos
  • Gregg C Fonarow
  • Barry H Greenberg
  • Adrian F Hernandez
  • Sadiya Khan
  • Michel Komajda
  • Marvin A Konstam
  • Peter P Liu
  • Aldo P Maggioni
  • Barry M Massie
  • John J McMurray
  • Mandeep Mehra
  • Marco Metra
  • John O'Connell
  • Christopher M O'Connor
  • Ileana L Pina
  • Piotr Ponikowski
  • Hani N Sabbah
  • John R Teerlink
  • James E Udelson
  • Clyde W Yancy
  • Faiez Zannad
  • Mihai Gheorghiade
چکیده

G. Michael Felker, MD, MHS; Peter S. Pang, MD; Kirkwood F. Adams, MD; John G.F. Cleland, MD; Gad Cotter, MD; Kenneth Dickstein, MD; Gerasimos S. Filippatos, MD; Gregg C. Fonarow, MD; Barry H. Greenberg, MD; Adrian F. Hernandez, MD, MHS; Sadiya Khan, MD; Michel Komajda, MD; Marvin A. Konstam, MD; Peter P. Liu, MD; Aldo P. Maggioni, MD; Barry M. Massie, MD; John J. McMurray, MD; Mandeep Mehra, MD; Marco Metra, MD; John O’Connell, MD; Christopher M. O’Connor, MD; Ileana L. Pina, MD; Piotr Ponikowski, MD; Hani N. Sabbah, PhD; John R. Teerlink, MD; James E. Udelson, MD; Clyde W. Yancy, MD; Faiez Zannad, MD, PhD; Mihai Gheorghiade, MD; on behalf of the International AHFS Working Group

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Shamrock aorta: unruptured sinus of Valsalva aneurysms in a patient with a prosthetic heart valve.

Fonarow GC, Greenberg BH, Hernandez AF, Khan S, Komajda M, Konstam MA, Liu PP, Maggioni AP, Massie BM, McMurray JJ, Mehra M, Metra M, O’Connell J, O’Connor CM, Pina IL, Ponikowski P, Sabbah HN, Teerlink JR, Udelson JE, Yancy CW, Zannad F, Gheorghiade M. Clinical trials of pharmacological therapies in acute heart failure syndromes: lessons learned and directions forward. Circ Heart Fail 2010;3:3...

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Special Report Clinical Trials of Pharmacological Therapies in Acute Heart Failure Syndromes Lessons Learned and Directions Forward

G. Michael Felker, MD, MHS; Peter S. Pang, MD; Kirkwood F. Adams, MD; John G.F. Cleland, MD; Gad Cotter, MD; Kenneth Dickstein, MD; Gerasimos S. Filippatos, MD; Gregg C. Fonarow, MD; Barry H. Greenberg, MD; Adrian F. Hernandez, MD, MHS; Sadiya Khan, MD; Michel Komajda, MD; Marvin A. Konstam, MD; Peter P. Liu, MD; Aldo P. Maggioni, MD; Barry M. Massie, MD; John J. McMurray, MD; Mandeep Mehra, MD...

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Acute heart failure syndromes: initial management.

Postdischarge mortality and morbidity from acute heart failure syndrome (AHFS) are high, affecting nearly half of all discharged patients within 90 days. Emergency department therapy remains largely empiric, with minimal evidence to support definitive recommendations to guide therapy. However, lessons learned from recent registries and trials suggest an approach to initial management based on c...

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Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure.

Substantial attention and resources have been directed to improving outcomes of patients with critical illnesses, in particular sepsis, but all recent clinical trials testing various interventions or strategies have failed to detect a robust benefit on mortality. Acute heart failure is also a critical illness, and although the underlying etiologies differ, acute heart failure and sepsis are cri...

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Therapy for acute heart failure syndromes.

The pharmacologic management of acute heart failure syndromes (AHFS) has changed little over the past 15 years. Traditional therapies, such as nitrates and loop diuretics, remain the mainstay of therapy, with inotropes reserved for patients who present in shock or an advanced low-output state. We review the use of these therapies in AHFS with added insights from recent clinical trials and regis...

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عنوان ژورنال:
  • Circulation. Heart failure

دوره 3 2  شماره 

صفحات  -

تاریخ انتشار 2010