[Metastatic renal cell carcinoma treated with everolimus--data from the RENIS Clinical Registry].
نویسندگان
چکیده
Everolimus is an oral mTOR kinase inhibitor approved for the treatment of patients with metastatic renal cell carcinoma (mRCC) progressing during or after treatment with vascular endothelial growth factor (VEGF)-targeted agents. Using the national RENIS clinical registry, we have retrospectively analysed outcomes of patients treated for mRCC with everolimus. A total of 78 patients were evaluable. Median progression-free survival from the start of everolimus therapy was 7 months (95% confidence interval 2-12 months). Partial response or stable disease was achieved in 69% of patients. Treatment toxicity was predictable and serious adverse events occurred in only 6% of patients the most common being respiratory toxicity. Everolimus therapy provides significant clinical benefit for heavily pretreated mRCC patients after failure of VEGF-targeted therapy.
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ورودعنوان ژورنال:
- Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
دوره 24 5 شماره
صفحات -
تاریخ انتشار 2011