LIPID NANOPARTICLE MEDIATED DRUG DELIVERy FOR SAFER CANCER TREATMENT: ExAMPLE OF PACLITAxEL
نویسندگان
چکیده
colloidal carriers composed of lipids attract much attention in the development of safer and more effective therapy of various diseases. the advantages of lipid-based nanoparticles are illustrated on the example of paclitaxel, a challenging chemotherapeutic drug for the development of a novel and more suitable dosage form for cancer treatment. paclitaxel is known for its water insolubility and serious side effects when administered by its conventional formulation (taxol). this paper reviews the reasons of further re-formulation of paclitaxel and summarizes the achievements of lipid nanoparticle-based formulations of this drug. KEywORDS solid lipid nanoparticles, nanostructured lipid carriers, lipid nanoparticles, paclitaxel, cancer treatment
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