Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.
نویسندگان
چکیده
A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC(50) value of 1 was moderate, ranging from 3 to 13 μM, depending on the cell line tested.
منابع مشابه
Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities.
As part of an ongoing investigation of filamentous fungi for anticancer leads, an active culture was identified from the Mycosynthetix library (MSX 70741, of the order Hypocreales, Ascomycota). The fungal extract exhibited cytotoxic activity against the H460 (human nonsmall cell lung carcinoma) cell line, and bioactivity-directed fractionation yielded peptaibols 1-12 and harzianums A (13) and B...
متن کاملProduction of Obionin A and Derivatives by the Sooty Blotch Fungus Microcyclospora malicola.
A multitude of sooty blotch and flyspeck fungi, mainly belonging to the Ascomycetes order Capnodiales, causes dark blemishes and flyspeck-like spots on apples worldwide. Different sooty blotch and flyspeck fungi can coexist in the same orchard and even on a single fruit. Our preceding experiments revealed an activity of Microcyclospora malicola strain 1930 against the anthracnose fungus Colleto...
متن کاملNotes on some endophytic fungi isolated from Quercus brantii in Dena, Kohgiluyeh and Boyer-Ahmad province
In this study, we report some endophytic fungi isolated from twigs of Quercus brantii in Dena region of Kohgiluyeh and Boyer-Ahmad province. The twigs were sampled from trees which had basidiocarps of the invasive basidiomycetous polypore fungus Inonotus krawtzewii on their trunk. Altogether, ca. 40 pure isolates were obtained. The ITS sequences were obtained for 16 isolates, and their phylogen...
متن کاملSpatial distribution of emission in Unidentified Infrared Bands from Midcourse Space Experiment Survey
Recently the Midcourse Space Experiment (MSX) has surveyed the Galactic plane in mainly four infrared bands between 6 and 25 μm. Two of these bands cover several Unidentified Infrared emission Bands (UIBs). With the aim of extracting the spatial distribution of the UIB emission on a large scale, a scheme has been developed to model the MSX data with emission in the UIBs alongwith the underlying...
متن کاملFe3O4@Polydopamine Core-Shell Nanocomposite as a Sorbent for Efficient Removal of Rhodamine B from Aqueous Solutions: Kinetic and Equilibrium Studies
In this work, a Fe3O4@polydopamine core-shell nanocomposite (Fe3O4/PDA) was synthesized through an in situ self-polymerization methods and was applied as a sorbent for Rhodamine B (RhB) removal. The synthetic procedure is simple and involves no organic solvents. The as-prepared Fe3O4/PDAnanocomposite was characterized by tran...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Tetrahedron letters
دوره 52 40 شماره
صفحات -
تاریخ انتشار 2011