T Serotonin Transporter :
نویسندگان
چکیده
April 2004 Volume 4, Issue 2 Dennis L. Murphy, Alicja Lerner, Gary Rudnick, and Klaus-Peter Lesch Laboratory of Clinical Science, Building 10, Room 3D41, 10 Center Drive, MSC 1264, NIMH, NIH, Bethesda, MD 20892; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510; Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany Gene, Genetic Disorders, and Pharmacogenetics
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Review of Metabolism, Transport and Role of Serotonin in the Body and the Relation between Serotonin and Diseases
Serotonin (5-hydroxytriptamine), one of the most important neurotransmitters, is synthesized from amino acid L-tryptophan in some neurons located in the central nervous system and intestine enterochromaffin cells . The role of this neurotransmitter is important and involves control of sexual behaviors, morality, sleep, pain, appetite, aggression, cardiovascular function and regulation of gut fu...
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-Components of the circadian system, the suprachiasmatic nucleus and the intergeniculate leaflet receive serotonin input from the raphe nuclei. Manipulations of serotonin neurotransmission disrupt cellular, electrophysiological, and behavioural responses of the circadian system to light, suggesting that serotonin plays a modulatory role in photic regulation of circadian rhythms. To study the re...
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