Electronic Supplementary Information: Fab on a Chip

نویسندگان

  • Matthias Imboden
  • Han Han
  • Thomas Stark
  • Evan Lowell
  • Jackson Chang
  • Flavio Pardo
  • Cristian Bolle
  • Pablo G. del Corro
  • David J. Bishop
چکیده

Matthias Imboden, Han Han, Thomas Stark, Evan Lowell, Jackson Chang, Flavio Pardo, Cristian Bolle, Pablo G. del Corro, and David J. Bishop Department of Electrical and Computer Engineering Department of Physics Division of Materials Science and Engineering Boston University, Brookline, Massachusetts 02446, USA Department of Mechanical Engineering Boston University, Boston, Massachusetts 02215, USA Bell Labs, Alcatel-Lucent, 600 Mountain Avenue, Murray Hill, New Jersey 07974, USA Instituto Balseiro, Centro Atómico Bariloche, Bariloche Río Negro 8400, Republic of Argentina

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Fully Integrated Range-Finder Based on the Line-Stripe Method

In this paper, an imaging chip for acquiring range information using by 0.35 μm CMOS technology and 5V power supply has been described. The system can extract range information without any mechanical movement and all the signal processing is done on the chip. All of the image sensors and mixed-signal processors are integrated in the chip. The design range is 1.5m-10m with 18 scales.

متن کامل

Global Mapping of Transcription Factor Binding Sites by Sequencing Chromatin Surrogates: a Perspective on Experimental Design, Data Analysis, and Open Problems

Mapping genome-wide binding sites of all transcription factors (TFs) in all biological contexts is a critical step toward understanding gene regulation. The state-of-the-art technologies for mapping transcription factor binding sites (TFBSs) couple chromatin immunoprecipitation (ChIP) with high-throughput sequencing (ChIP-seq) or tiling array hybridization (ChIP-chip). These technologies have l...

متن کامل

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation† †Electronic supplementary information (ESI) available: 1H and 13C spectra for all novel compounds, and ES-MS spectra for all reactions with proteins described herein. See DOI: 10.1039/c3cc45220dClick here for additional data file.

In this communication we describe a novel acid-cleavable linker strategy for antibody-drug conjugation. Functional disulfide bridging of the single interchain disulfide bond of a trastuzumab Fab fragment yields a homogeneous antibody-drug conjugate bearing a thiomaleamic acid linker. This linker is stable at physiological pH and temperature, but quantitatively cleaves at lysosomal pH to release...

متن کامل

Probabilistic partitioning methods to find significant patterns in ChIP-Seq data

MOTIVATION We have witnessed an enormous increase in ChIP-Seq data for histone modifications in the past few years. Discovering significant patterns in these data is an important problem for understanding biological mechanisms. RESULTS We propose probabilistic partitioning methods to discover significant patterns in ChIP-Seq data. Our methods take into account signal magnitude, shape, strand ...

متن کامل

Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4mb00354c Click here for additional data file.

Transcription factors play a key role in the development of a disease. ChIP-sequencing has become a preferred technique to investigate genome-wide binding patterns of transcription factors in vivo. Although this technology has led to many important discoveries, the rapidly increasing number of publicly available ChIP-sequencing datasets still remains a largely unexplored resource. Using a compe...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014