CLINICAL TRIALS AND OBSERVATIONS Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)
نویسندگان
چکیده
1Immunology Research Centre Bu-Ali Research Institute, 2Department of Pathology and Laboratory Medicine, and 3Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 4Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; 5Oncovirologie et Biothérapies, Centre National de la Recherche Scientifique (CNRS) FRE 3011, Université Claude Bernard, Centre Léon Bérard, Hopital Edouard Herriot, Lyon, France; 6Department of Dermatology, and 7Microbiology and Virology Research Center, Bu-Ali Research institute, Mashhad University of Medical Sciences, Mashhad, Iran; 8Department of Pharmaceutical Biotechnology, College of Pharmacy, Tehran University of Medical Science, Tehran, Iran; 9CNRS Unité Mixte de Recherche (UMR) 7151, Laboratoire Associé au Comité de Paris de la Ligue contre le Cancer, Paris, France; and 10CNRS UMR 8603 and Department of Hematology, Necker Hospital, Paris, France
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Single-agent arsenic trioxide in the treatment of children with newly diagnosed acute promyelocytic leukemia
The aim of this study was to determine the efficacy and safety of treatment of pediatric acute promyelocytic leukemia (APL) with single-agent arsenic trioxide (ATO). A total of 19 children (< 15 years of age) with newly diagnosed APL were treated with single-agent ATO for remission induction and postremission therapy. Seventeen of the children (89.5%) achieved complete hematologic remission, an...
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Arsenic trioxide, as a single agent, has proven efficacy in inducing molecular remission in patients with acute promyelocytic leukemia (APL). There is limited longterm outcome data with single-agent As 2 O3 in the management of newly diagnosed cases of APL. Between January 1998 to December 2004, 72 newly diagnosed cases of APL were treated with a regimen of single-agent As2O3 at our center. Com...
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Arsenic trioxide (As2O3) is a highly effective treatment for patients with relapsed acute promyelocytic leukemia (APL); its role as consolidation treatment for patients in first remission has not been defined. We randomized 481 patients (age > 15 years) with untreated APL to either a standard induction regimen of tretinoin, cytarabine, and daunorubicin, followed by 2 courses of consolidation th...
متن کاملMaintenance therapy with all-trans retinoic acid and arsenic trioxide improves relapse-free survival in adults with low- to intermediate-risk acute promyelocytic leukemia who have achieved complete remission after consolidation therapy
BACKGROUND Currently, the optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who have achieved complete remission (CR) after completing consolidation chemotherapy remains controversial. The comparative effectiveness of the all-trans retinoic acid (ATRA) plus arsenic trioxide (As2O3) maintenance strategy with classic ATRA plus chemotherapy has not been evaluated. In...
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