Progressive neurological dysfunction during latent HIV infection.
نویسندگان
چکیده
OBJECTIVE--To determine whether the delayed conduction through the spinal cord and peripheral nerves seen in patients with AIDS is related to infection with HIV or to the presence of an immunodeficient state. DESIGN--Two year prospective follow up study of electrophysiological measurements in subjects positive for HIV antibody but without AIDS. SETTING--HIV screening clinic and clinical departments in a university hospital in Copenhagen, Denmark. SUBJECTS--Twelve homosexual men positive for HIV antibody who had not developed AIDS. RESULTS--Eight latencies were measured: from the ankle to T12, the wrist to C7, T12 to the cerebral cortex, C7 to the cerebral cortex, the ankle to the gluteal crease (tibial nerve), the gluteal crease to T12, the wrist to Erb's point (median nerve), and Erb's point to C7. Spinal latencies increased in all subjects at C7 by a mean of 4.2% (SE 0.9%) and in all except one at T12 by a mean of 5.5% (1.0%). The conduction time from the gluteal crease to T12 was increased by a mean of 32.0% (5.0%) whereas that in the median and tibial nerves by only 5.6% (1.0%) and 2.2% (2.2%) respectively. CONCLUSIONS--A mild and slowly progressive peripheral neuropathy of the axonal type and a more severe progressive myelopathy or myeloradiculopathy occur concomitantly with early HIV infection, possibly as the result of a direct neurotropic action of HIV.
منابع مشابه
Neurological and Epidemiological Aspects of a BoHV-5 Meningoencephalitis Outbreak
Bovine herpesvirus 5 is a DNA virus that has been associated with meningoencephalitis in young cattle. While its clinical diagnosis is obscured by other major diseases that also produce similar neurological disease in cattle, the use of conventional virological techniques is hampered by the establishment of a lifelong latent infection in the host and the difficulty in differentiating BoHV-1 and...
متن کاملIsolated cortical blindness without simultaneous neurological involvement in progressive multifocal leukoencephalopathy in a patient with human immune deficiency virus infection
BACKGROUND This is a case report of cortical blindness in a HIV-positive patient with progressive multifocal leukoencephalopathy (PML) without any other associated neurological dysfunction. FINDINGS Young HIV-positive patient presented to us with sudden profound visual loss. On examination and further investigation, we have diagnosed cortical blindness without any other focal neurological def...
متن کاملPathogenic mechanisms of neuronal damage in the AIDS dementia complex.
It has become clear that infection with HIV1 is capable of causing a progressive syndrome of neurological disease that is not strictly dependent upon the state of immunosuppression in the infected individual.' Although the central nervous system (CNS) is often the target of opportunistic infections in the later stages of AIDS related complex (ARC) or in AIDS itself, the AIDS dementia complex (A...
متن کاملThrombotic microangiopathy and cytomegalovirus disease in patients infected with human immunodeficiency virus.
Thrombotic microangiopathy (TMA) can occur during the course of human immunodeficiency virus (HIV) infection. Clinical and pathological data for 29 patients with TMA and HIV infection were recorded. In a retrospective case-control study, we analyzed the link between opportunistic infections or drug therapies and TMA. Twenty-five patients (mean CD4+ cell count +/- SD, 71.9 +/- 18.3/mm3) had rena...
متن کاملScreening for Syphilis: Brief Update for the U.S. Preventive Services Task Force
Syphilis is a systemic infectious disease caused by sexual or congenital transmission of the bacterium Treponema pallidum (T. pallidum). Syphilis causes a variety of symptoms corresponding to stages of infection (primary, secondary, tertiary) and no symptoms during latent stages. Late-stage syphilis includes gummatous, cardiovascular, and neurological complications that can lead to significant ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- BMJ
دوره 299 6693 شماره
صفحات -
تاریخ انتشار 1989