Pharmacokinetic Assessment of Tylosin Concomitantly Administered with Two Anticoccidials Diclazuril and halofuginone in Broiler Chickens

Disposition pharmacokinetic of tylosin concomitantly administrered with either diclazuril (Clinacox ) (1 ® mg/kg feed) and halofuginone (Stenorol ) (3 mg/kg feed) were studied following a single IV, oral and IM ® administrations in broiler chickens. Following IV injection, tylosin serum concentration was best to be 1⁄2 á described by a 2-compartment open model. Diclazuril resulted in a short distribution half-life (t ) (8.46 ± 0.28 12 21 area min.) with higher K /K ratio and Vd (3.12 ± 0.13 and 12.96 ± 0.82 L/kg, respectively. In contrast 1⁄2 á 12 21 area halofuginone induced a prolonged t (18.52 ± 0.64 min.) with lowered K / and Vd (1.26 ± 0.12 and 5.79 ± 0.38 L/kg, respectively) compared with drug alone (12.13 ± 0.59 min, 2.01 ± 0.16 and 8.34 ± 0.7 L/kg, 1⁄2 ab respectively). Following oral dosing the absorption half life (t ) was 16.72 ± 1.13, 8.29 ± 0.67 and 40.95 ± m ax 5.94 min. for tylosin alone and in presence of diclazuril and halofuginone respectively. C value were 1.24 ± 0.074 and 1.59 ± 0.142 μg/ml at 0.84 ± 0.06 and 2.06 ± 0.14 hours in presence of diclazuril and m ax halofuginone respectively. However C was 0.92 ± 0.12 μg/ml reached at 1.58 ± 0.09 h for tylosin alone. 1⁄2 ab Following IM injection t was 10.25 ± 1.08, 4.29 ± 0.47 and 3.57 ± 0.146 min. for drug alone and in m ax concomitant with diclazuril and halofuginone respectively. C was 1.83 ± 0.064 μg/ml reached at 0.49 ± 0.083 h and 4.67 ± 0.28 μg/ml at 0.32 ± 0.024 h for drug in presence of diclazuril and halofuginone respectively compared to 0.408 ± 0.52 μg/ml attained at 0.79 ± 0.052 h for drug alone (21.54 ± 1.86%).