Nox4 mediates TGF- 1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells
نویسندگان
چکیده
Anne Sturrock, Thomas P. Huecksteadt, Kimberly Norman, Karl Sanders, Thomas M. Murphy, Pasquale Chitano, Kimberly Wilson, John R. Hoidal, and Thomas P. Kennedy Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah Health Sciences Center and Veterans Administration Medical Center, Salt Lake City, Utah; Division of Pediatric Pulmonary Diseases, Duke University Medical Center, Durham, North Carolina; and Department of Biology, Winthrop University, Rock Hill, South Carolina
منابع مشابه
Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells.
Transforming growth factor-beta1 (TGF-beta1) plays a pivotal role in increasing airway smooth muscle mass in severe asthma by inducing proliferation and hypertrophy of human airway smooth muscle. The mechanism(s) for these effects of TGF-beta1 have not been fully elucidated. In this study, we demonstrate that TGF-beta1 is a potent inducer of expression of the nonphagocyte NAD(P)H oxidase cataly...
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Persistent hypoxia can cause pulmonary arterial hypertension (PAH) that may be associated with significant remodeling of the pulmonary arteries, including smooth muscle cell proliferation and hypertrophy. We previously demonstrated that the NADPH oxidase homologue NOX4 mediates human pulmonary artery smooth muscle cell (HPASMC) proliferation by transforming growth factorβ1 (TGF-β1). We now show...
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BACKGROUND Airway remodeling in asthma is the result of increased expression of connective tissue proteins, airway smooth muscle cell (ASMC) hyperplasia and hypertrophy. TGF-beta1 has been found to increase ASMC proliferation. The activation of mitogen-activated protein kinases (MAPKs), p38, ERK, and JNK, is critical to the signal transduction associated with cell proliferation. In the present ...
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Transforming growth factor-β1 (TGF- β1) and thrombospondin-1 (TSP-1) are hypoxia-responsive mitogens that promote vascular smooth muscle cell (SMC) proliferation, a critical event in the pathogenesis of pulmonary hypertension (PH). We previously demonstrated that hypoxia-induced human pulmonary artery smooth muscle (HPASMC) cell proliferation and expression of the NADPH oxidase subunit, Nox4, w...
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