Etiopathophysiology of disseminated intravascular coagulation.

نویسندگان

  • S Bakhshi
  • L S Arya
چکیده

Disseminated intravascular coagulation (DIC) involves activation of clotting as well as fibrinolytic pathways. Thrombosis from thrombin release results in end-organ damage, whereas consumption of coagulation factors results in bleeding. Sepsis is the commonest cause of DIC. The consumption of antithrombin in sepsis abrogates its anti-inflammatory role and so its low level is a poor prognostic marker in sepsis. The increased release of plasminogen activator inhibitor-1 (PAI-1) as seen in sepsis decreases fibrinolysis and promotes increased microvascular thrombosis. Here, we discuss the role of inhibitors of coagulation, cytokines, kinins, complement and vasoactive peptides in DIC.

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عنوان ژورنال:
  • The Journal of the Association of Physicians of India

دوره 51  شماره 

صفحات  -

تاریخ انتشار 2003