Molecular Umbrella–Amphotericin B Conjugates
نویسندگان
چکیده
A tetrawalled and an octawalled molecular umbrella conjugate of amphotericin B (AmB) have been synthesized. Both conjugates exhibit high water solubility, a low tendency to aggregate, negligible hemolytic activity at 100 μM, and an ability to release a derivative of AmB under reducing conditions that exhibits high antifungal activity. Whereas the larger, octawalled conjugate shows slight adsorption to liposomal membranes and an ability to cross them by passive transport, the tetrawalled analogue shows significant adsorption and much lower bilayer transport activity. The potential of molecular umbrella-AmB conjugates as therapeutic agents is briefly discussed.
منابع مشابه
Correction to Molecular Umbrella–Amphotericin B Conjugates
A ll sterols that appear on the right side of each molecular umbrella framework shown in the Abstract, Text, and Table of Contents should have been drawn with the natural stereochemistry of cholic acid shown below and not that of its enantiomer: This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations ...
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عنوان ژورنال:
دوره 25 شماره
صفحات -
تاریخ انتشار 2014