Computational Reconstruction of the Carbon Fixation Pathway in Synechococcus Sp. Wh 8102

The carbon fixation pathway plays an essential role in the primary production and natural carbon recycling process. In this paper, we present a computational model of the carbon fixation pathway in the marine cyanobacterium Synechococcus sp. WH 8102 (SYNWH8102), using our recently developed computational protocol for inference of regulatory and signaling pathways. The results of our pathway prediction include: (a) the pathway model consists of major components of the carbon fixation pathway reported in the literature. (b) Eight additional gene candidates were added into the model, making our pathway model more complete. (c) Two predicted transcription factor binding sites were found in the upstream regions of multiple genes involved in the carbon fixation pathway. (d) A list of more than 200 potential candidates associated with the pathway was also obtained for further experimental validation.