Reactivation of chicken erythrocyte nuclei in heterokaryons results in expression of adult chicken globin genes.
نویسندگان
چکیده
Activation of chicken globin gene transcription has been demonstrated in chicken erythrocyte--rat L6 myoblast heterokaryons. The globin mRNA is polyadenylylated and is translated into adult chicken alpha A-, alpha D-, and beta-globin polypeptides. No fetal globin mRNA or globin polypeptides were detected. Heterokaryons between chicken erythrocytes and mouse neuroblastoma cells or hamster BHK cells also synthesized adult chicken globins.
منابع مشابه
Pattern of chick gene activation in chick erythrocyte heterokaryons
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 78 10 شماره
صفحات -
تاریخ انتشار 1981