Imidazolium Salts with Dihydroxyacetophenone Skeleton with Anticipated Anticancer Activity. II

We report herein a feasible study concerning syntheses and structure of some diazolium salts with dihydroxyacetophenone skeleton of anticipated anticancer activity. A fast, general and facile method for preparation of 1,3-diazol salts via N-alkylation reactions under conventional heating and microwave irradiation is presented. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of used solvents was reduced substantially. Consequently, the microwave assisted alkylation of imidazole derivatives could be considered eco-friendly. The structure of the newly compounds were assigned without doubts by elemental and spectral analysis: 1H NMR, 13C NMR, 2D-COSY, 2D-HETCOR (HMQC), long range 2D-HETCOR (HMBC).