Production of penicillin with waste mycelium Penicillium chrysogenum as the sole source of nitrogen.

In a preliminary communication (Ghosh, 1959) it was reported that fresh and wet mycelium of Penicillium chrysogenum, as obtained from a rotary filter in a penicillin plant, could be well utilized as the sole source of nitrogen for penicillin production by the mold either in shaken flask or in aerated and agitated large fermentors. The waste mycelium did not need any pretreatment whatsoever and could be directly incorporated into the fermentation medium and sterilized as usual. The details of this investigation are presented here.